Our mission is to empower and enable patient & public involvement in motor neuron disorders research

“Hot off the press” Lay summaries of recently published research results

To support our patients and the public to understand and interpret recently published papers of MND research, which often contain very complex scientific concepts and technical terminology, researchers at SITraN have developed a Hot off the press resource of research summaries that are written in layman’s terms, or lay summaries. These summaries are aimed to provide an overview of some of the biggest publications in an easy-to-understand way, using simple language and removing the “scientific jargon”.

Below is a table of the lay summaries that have been written by the SITraN researchers. You can browse the table, sort the columns using the up/down arrows at the side of each column header, or search for specific words/topics using the search box.

We hope you find this resource useful. We will add to it on a regular basis.

Layman's study title & link to the summaryType of researchTitle of scientific publication and details (with link to original paper, if available)Date paper published (year, month, date)Date lay summary publishedLay summary author
The nutritional care of people living with amyotrophic lateral sclerosis
(ALS); a dietician’s view
SurveyThe nutritional care of people living with amyotrophic lateral sclerosis
(ALS); a dietician’s view
DOI: 10.1111/jhn.12900
2021-03-31October 2021Sarah Roscoe, PhD student, University of Sheffield
Novel drug shows a reduction in central nervous system (CNS) inflammation and improvement of disease symptoms in a mouse model of ALSLaboratory studyA Novel Anti-Inflammatory D-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model. Post et al. 2021. Molecules.
DOI: 1420-3049/26/6/1590
2021-03-13September 2021Amy Keerie PhD student, University of Sheffield
A prolonged study following ALS patients found circulating biomarkers in the blood that can define disease prognosis and progression in ALS patientsClinical research trialA longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients. Cell Death Discov. 7, 4 (2021)
DOI: s41420-020-00397-6
2021-05-11April 2021Anushka Bhargava, PhD student, University of Sheffield
The gut-brain axis filling in the blanksLaboratory studyPotential roles of gut microbiome and metabolites in modulating ALS in mice
DOI: 10.1038/s41586-019-1443-5

2019-07-22April 2021Mara Luciana Floare, PhD student, University of Sheffield
Mara Floare - ALS skin fibroblasts reveal oxidative stress and ERK1-2-mediated cytoplasmic localization of TDP-43ALS skin fibroblasts reveal oxidative stress and ERK1/2-mediated cytoplasmic localization of TDP-43
DOI: 10.1016/j.cellsig.2020.109591
2020-02-29March 2021Mara Floare, PhD student, University of Sheffield
Jonathan George - Improving clinical trial outcomes in amyotrophic lateral sclerosisImproving clinical trial outcomes in amyotrophic lateral sclerosisN/AFebruary 2021Jonathan George, PhD student, University of Sheffield
Amy Keerie - Lessons learnt from a new C9orf72 mouse model of ALSLaboratory studyLessons learnt from a new C9orf72 mouse model of ALS
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.
Nguyen et al. 2020. DOI:j.neuron.2020.09.009
Liu et al. 2016. DOI: j.neuron.2016.04.005
Mordes et al. 2020.DOI:j.neuron.2020.08.009
2020-11-25February 2021Amy Keerie PhD student, University of Sheffield
SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALSSOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS
DOI: 10.1056/NEJMoa2005056)
2020-07-09February 2021Ben Hall, PhD student, University of Sheffield
CYLD is a causative gene for frontotemporal dementia-amyotrophic lateral sclerosisCYLD is a causative gene for frontotemporal dementia-amyotrophic lateral sclerosis
DOI: 10.1093/brain/awaa039
2020-03-01February 2021Ben Hall, PhD student, University of Sheffield
Results from Sodium Phenylbutyrate-Taurursodiol for ALSClinical research trialTrial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral SclerosisTrial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis
DOI: 10.1056/NEJMoa1916945
2020-09-03November 2020Ben Hall, PhD student, University of Sheffield
Results from a large-scale analysis study linking weight loss to ALS geneticssStatistical analysis of results from multiple clinical studiesGenome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus is Associated with ALS and Links Weight Loss to the Disease Genetics, (Iacoangeli et al., October 2020, Cell Reports, Vol 33, Issue 4)
DOI: 10.1016/j.celrep.2020.108323
2020-11-27November 2020Sarah Roscoe, PhD student, University of Sheffield
Results from a clinical trial looking at using artificially engineered RNA (single stranded DNA) to reduce the levels of a mutant protein involved in some cases of MNDClinical research studyPhase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS (Miller et al., July 2020, The New England Journal of Medicine, Vol 383, No. 2)
DOI: 10.1056/NEJMoa2003715
2020-07-09August 2020Jessica Allsop, Research Assistant, University of Sheffield
Results from scientific research looking at injecting an altered virus into an MND mouse model to target a and reduce the levels of a specific mutated gene in MNDLaboratory studyIntralingual and Intrapleural AAV Gene Therapy Prolongs Survival in a SOD1 ALS Mouse Model (Keeler et al., December 2019, Molecular Therapy: Methods & Clinical Development, Volume 17)
DOI: 10.1016/j.omtm.2019.12.007
2020-06-12July 2020Jessica Allsop, Research Assistant, University of Sheffield
2020-06 Reduced C9orf72 function exaerbates toxicityLaboratory studyReduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 (Zhu et al., April 2020, Nature Neuroscience, Issue 23)
DOI: 10.1038/s41593-020-0619-5
2020-04-13June 2020Ben Hall, PhD student, University of Sheffield
Results from scientific research looking into using a naturally occurring compound to combat the effects of hypoxia (oxygen deprivation) in a mouse model of MNDLaboratory study6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (Hoshino, T. et al., March 2020, Neuroscience Research)
DOI: 10.1016/j.neures.2020.02.011
2020-03-04June 2020Jessica Allsop, Research Assistant, University of Sheffield
A new method for modelling cell to cell interaction in disease Laboratory studySystematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
DOI: s41467-020-19177-y
2020-04-11May 2020Ben Hall, PhD student, University of Sheffield